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The Breast cancer treatments With chemotherapy they are decided based on their molecular classification and its hormonal receptors (RH). However, various studies have demonstrated the effectiveness of fungi use In this type of pathologies, especially on two levels:
- Prevention: to reduce prevalence and avoid recurrence.
- Adjuvant treatment: to complement conventional treatment by reducing adverse effects of other treatments.
Studies on prevention in breast cancer
In breast cancer prevention, the study conducted by Australian scientists in 2009 (Zhang et al. 2009). In this, they showed that Chinese women who consumed 4 g of dehydrated mushrooms daily and a 1 g of green tea, They reduced by 89% the risk of breast cancer.
In fact, the prevalence of breast cancer in the rural areas of China or Japan is much lower than that of urban areas, which is also linked to the type of diet that follows (fundamentally based on mushrooms and rice), as well as their lifestyle.
According to the figures managed by the UN, almost a third of deaths caused by cancer is due to dietary and behavioral factors, among which a high body mass index, low consumption of fruits and vegetables, lack of physical activity and alcohol and tobacco consumption.
Studies on adjuvant treatments in breast cancer
Some bioactive compounds derived from fungi, in concentrations with therapeutic action (such as extracts), have proven to be a complement that can improve the quality of life of the patient and increase survival Combined with chemo and radiotherapy treatments.
What are adjuvant treatments?
As stated in various medical texts, a adjuvant is a treatment that "contributes to the improvement of the quality of life in general or in a specific process." In this definition, antidepressants and anxiolytics would enter, but also other substances such as laxatives.
Currently, in this definition the support care that aim to complement the therapies directed to prevent infections, manage the toxicities associated with chemotherapy, make recommendations on lifestyle, etc. would also enter complement.
A 2010 study showed that the early integration of support treatment, in contributing with conventional treatment, increases the quality of life, mood and improves the prognosis of patients.
Reduction in side effects
An article published in 2001 (Mayell, 2001) includes the effects of the combination of fungal extracts with chemotherapy, radiotherapy and hormonal radiotherapy treatments. The observed results showed that this combination:
- They help reduce naúseas, pain, loss of appetite and hair, etc.
- It can show a synergistic effect on tumor regression.
Figure. Decreased side effects of chemotherapy using Maitake (Frondosa Tap) (Mayell, 2001).
Tumor growth inhibition
According to a study published in 2006 (Juic J et al., 2006), in cell tests, increasing doses of extracts of Ganoderma lucidum Decreases the proliferation of breast cancer cells.
Figure. Dose effect- and time-dependent of ganoderMerMantriol, a component of ganoderma lucidum, in the proliferation of breast cancer cells hormone-dependent mda-Mda-231 (Jiang et al., 2011).
Drug interaction
It has been shown that the use of fungi as an adjuvant in the treatment of first -line chemotherapy or radiotherapy does not interfere with the effectiveness of the protocolized clinical treatment. There are numerous studies that demonstrate the compatibility of mycotherapy with chemotherapeutic treatments:
- Use of Taxol With the extract of Agaricus Blazei or of Edodes lentinula (Ahn et al., 2004; Okuno and one, 2011).
- Use of carboplatin and of VP16 (Etoposide) with extract of A. Blazei (Ahn et al., 2004).
- Use of Cisplatino With the extract of L. Edodes and slowly, a beta-glucan obtained from L. Edodes (Hirose et al., 2007; Ina et al., 2011).
- Use of PLACLITAXEL with lentinan (Kubota et al., 2009), irinotecan, 5-Fluorouracil and Levofolinato With extract of L. Edodes (Okuno et al., 2011).
- The effectiveness of Ganoderma lucidum to reduce the nephrotoxicity of certain chemotherapets such as Cisplatin (Kao et al., 2013).
Breast cancer
More information about breast cancer and adjuvant treatments developed from fungi
Medina Foundation
The metabolism of conventional drugs is carried out through hepatic cytochromes (P450), which do not coincide with cytochromes involved in the assimilation of fungal preparations.
Hifas da Terra has its own fungal extracts that have been validated by various scientific studies in terms of their effectiveness and the absence of interaction with cytochromes that involve other drugs.
It has been shown that Hifas Da Terra extracts have a low possibility of interaction In vivo with other medications that metabolize through cytochrome P450 (Medina Foundation).
In addition to medication absence, extracts can act synergisticly with conventional treatments, improving adherence to patient treatment and helping to complete the cycles of treatments by minimizing their side effects.
Hifas Da Terra Professional Area
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Summary
Mushrooms have an important role in the maintenance of well -being, but in high concentrations they are also of interest in the prevention and complementary treatment of breast cancer, as evidenced in various publications. These investigations, as well as the non -drug interaction of some of their extracts predict a long journey in their therapeutic applications.
Bibliographic references
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