What Galenica choose: 100% natural extracts or pharmaceutical forms of modified liberation (FFLM), known as micrographs? In mycotherapy formulations, as is the case with all food supplements and medicines, we must choose what a galanic form or pharmacological formula is adequate to guarantee, in the first instance, the bioavailability of the active substance. In the market we find pills, roads, tablets, capsules ... different forms of presentation that respond to a main objective: to ensure that the active substance reaches the point of action in the proper concentration.
In addition to favoring bioavailability, the choice of one or another galenic way can aim to improve the appearance and taste of the product, but it can also be decisive when reducing interaction with other drugs or food.
Why choose classic fungi extract formulas
Fungi constitute one of the most important therapeutic arsenals in the natural world. Each of the fungal species consists of hundreds of active molecules such as polysaccharides (including β-glucans), triterpenoids (including sterols), phenols, peptides, proteins, polysaccharide-protein complexes, etc.
- BioDisponability of extracts As we explain in the following image, there is evidence that the galenic form of natural extracts allows β-glucans to fulfill their therapeutic function thanks to interaction with immune system cells.
Image text references: 1. Masuda y, Inoue H, Ohta H, Miyake A, Konishi M, Nanba H (2013) Oral Administration of Soluble β-GLUCANS EXTRACted from Frondosa Frondosa Grifola Systemic Antitumor Immune Response and Decasses Immunosuppression in Tumor-Bearing Mice. International Journal of Cancer 133, 108-120. / 2. Chan GCF, Chan WK, Sze Dmy (2009) The Effects of β-Glucan on Human Immune and Cancer Cells. Journal of Hematology & Oncology 2:25.- Formula chosen in scientific studies In Hifas mycotherapy formulations da Terra We only work with 100% natural extracts. Solid forms (standardized powder extract) classic that offer high ratios of active substance under optimal extraction conditions and that are chosen in the thousands of scientific publications of studies In vitro and In vivo, hundreds of clinical trials and patents. These are, therefore, the formulations from which we can talk about demonstrated scientific results.
- Absence of medication interaction The Medina Foundation, a center of excellence in innovative medication research in Andalusia, has evaluated the interaction of hyphae extracts da terra with other medications. The conclusions of this study demonstrate a low possibility of drug interactions In vivo by inhibition of the CYP450.
- No additives and synthetic coatings, 100% extract Hifas Micasalud Da Terra extracts They do not contain additives or synthetic coatings. In addition, high capsule extract concentrations They allow reaching the therapeutic dose with lower number of capsules per day.
Limitations of pharmaceutical forms of modified release (FFLM) or micrographs
- In mycotherapy they are also prescribed Pharmaceutical forms of modified release (FFLM) although with less scientific guarantee than natural extracts. These forms have been chosen by the pharmaceutical industry to present substances with narrow therapeutic margin, adverse effects related to plasma concentration, short action duration and/or pharmacological tolerance with constant plasma levels.
- On many occasions, your choice justifies a Less amount of capsule/tablet extract and the use of Other plant extracts that They get fat The product without therapeutic justification. In addition, they normally include Synthetic and even additive coatings that make the product more attractive at the organoleptic level.
- These are some of the Micrographic limitations, but they are not the only ones:
- There are no clinical data, publications or scientific essays on the use of FFLM or micrographs.
- The absence of comparative studies or clinical trials of efficacy or safety From these formulations it is necessary to limit its use.
- There are pathophysiological aspects that must be taken into consideration and that can again limit their therapeutic application: The speed of release FFLM can be altered by the intestinal transit situation. Modified release can limit therapeutic function in patients with rapid transit (irritable intestine syndrome, hyperthyroidism, partial gastrectomy, etc.) because the release of the active substance has not been completed.
- The inclusion of various compounds that are not fungal extracts in FFLM could interfere with the absorption of active molecules.
- No studies have been developed medication interactions or liver safety with the extracts included in the FFLM or with the combination of fungal extracts and plant extracts (achicoria, astragalus, marian thistle, etc.).
Other reasons why choose HDT extracts
In addition to the strictly related points to the galenic form, there are other issues that differentiate and reinforce the experience and scientific work of a brand like Hifas da Terra:
Certified European Ecological Production and Product Traceability The process of elaboration of our products, from the crop to the final encapsulation, is controlled by the relevant food security agencies and by the quality organs of the European ecological production.
Compliance with labeling regulations All our products comply with the relevant legislation on labeling: food information provided to the consumer, information required as food supplements and information about organisms that certify the ecological production of the product. In addition, our products are registered Spanish Agency for Consumption, Food Security and Nutrition (Aecosan) and by the competent European agencies in Belgium.
Pharmaceutical standards of excellence Hifas Da Terra extracts have the GMP certification (Good manufacturing practices), guarantee that production is uniform and controlled, according to pharmaceutical safety standards.
Security and trust In Hifas da Terra we are scientists (doctors, biologists, chemicals, etc.) specialized in the study of fungi and in the development of new mycotherapy solutions for health care. Through our biomedical department we offer personalized advice and design protocols appropriate to specific needs, Do you want to contact us?