Lyme stroke: a disabled disease

According to the Carlos III Health Institute (Ministry of Science and Innovation), the Lyme disease It is one Bacterial infection emerging in Europe that contracts after the bite of a Genus tick Ixodes infected by the Borrelia Burgdorferi.

Lyme's disease is a zoonosis (Pathology that can pass from animals to people) that can present a nonspecific pseudo -speaking picture accompanied by the call Erythema Migrans, a characteristic injury of the disease.

The infection is usually asymptomatic, but in some cases it can lead to a disabled condition (Durable joint pain, partial paralysis of the limbs, etc.). It is important to note that Lyme's disease is not contagious. [1]

Post -treatment syndrome present in 20% of patients

The syndrome Post -treatment of Lyme disease (PTLDS) is a condition in which patients experience persistent symptoms of fatigue, pain and cognitive difficulties After 6 months of antibiotic treatment for acute Lyme disease.

To a 20% of patients with Lyme disease develop SDPT. By definition, Lyme Post -treatment syndrome includes a previous diagnosis of Lyme disease, recurring symptoms of fatigue, musculoskeletal pain or cognitive deterioration, which persist for at least six months after completing the antibiotic treatment. 

Although the background of tick sting or eruption migratory erythematous (EEM) allow a rapid diagnosis, Few patients are aware of the tick sting Before infection and incidence of EEM eruptions, according to the geographical location and the species of Borrelia, so some patients never develop EEM.

Chronic manifestations of Lyme's disease

Therefore, the chronic manifestations of Lyme's disease can be the result of diagnosis delays. The chronic manifestations of Lyme's disease can also be the result of the Failure of antibiotic therapy, since commonly prescribed treatments may not be healing. Researchers have discovered that patients with acute and/or long evolution Lyme disease often remain sick for long periods after treatment and that some see their disease progress despite treatment. [2]

Tick ​​bites and Lyme disease

The chronic manifestations of Lyme's disease associate with significant and durable alterations of the quality of life In certain patients. The quality of life scores of the participants in the four trials of portraction of the Lyme disease sponsored by the National Health Institutes (NIH) were systematically lower than those of healthy populations. In two of these essays, persistent symptoms were so serious that they interfere with daily functioning. [3]

Det from the tick sting: the corporate impact of Lyme's disease

He economic impact of the chronic manifestations of Lyme's disease It can be considerable. The responses to a survey of diagnosed patients of Lyme's disease (based on the surveillance criteria of the centers for disease control and prevention) and those who were sick for 6 months or more revealed that 39.4% and 28.3%, respectively, stopped working or reduced their workday and 37.3% spent at least 5,000 dollars in pocket expenses related to Lyme disease [4].

Despite the important impact that the chronic manifestations of Lyme's disease can have on people, their families and the economy, there is still no widely accepted definition of chronic Lyme disease [3].

The Infectious Diseases Society of America (IDSA) has proposed inclusion criteria for the diagnosis of Lyme Post-treatment disease, or PTLDs, including a previous Lyme disease diagnosis, stabilization of symptoms after antibiotic treatment, and recurring symptoms of fatigue, musculoskeletal pain, or complaints of cognitive difficulties that persist for at least 6 months after the end of the treatment antibiotic [5].

Se ha acordado un proyecto de investigación para estudiar los efectos de la supplementation with Specific extracts of pure fungi of Hifas da Terra In PTLDS to study A group of 19 people, with special attention to variations in fatigue and pain.

New studies for the management of symptoms

• Hifas da Terra has conducted a study on the Chronic Lyme (Lyme disease syndrome post -treatment) associated with mycotherapy. 
• This study intended to investigate the effects of mycotherapy with Reishi (Ganoderma lucidum) and León hair (Hericium erinaceus) For 3 months in people with chronic Lyme disease (PTLDS).
• This study was carried out in collaboration with Déborah jaclin, naturopath and association coordinator Réseau Lyme Europe.

Numerous scientific studies have evaluated the anti -inflammatory action of the fungus Ganoderma lucidum (Reishi) [6,7,8,9,10]. This species, very employed in traditional oriental medicine, también se ha estudiado en los Fatigue problems [10,11], which are frequently observed in people with Chronic Lyme disease.

On the other hand, the compounds present in the MElena de León (Hericium erinaceus) se have studied at the level cognitive [12, 13,14] and digestive [15,16,17]. The restoration of a optimal intestinal microbiota allows a better assimilation of the active ingredients of pure fungi, as well as Food in general. 

Thus, the Complementary support offered by Reishi and Mamena de León They could help improve the symptoms that persist After the conventional treatment of post-andme syndrome.

Details of the study of Lyme with Reishi extracts and León hair

To participate in the study, people had to be between 18 and 65 and a previous diagnosis of Lyme disease -That's, an essay Immunoenzimatic (Elisa) positive initial, followed by a POSITIVE WESTERN BLOT TEST, with or without erythema Migrans-, having also received an initial antibiotic treatment, not having taken antibiotics during the previous 3 weeks and having elapsed more than 6 months between the initial diagnosis and the Advanced disease phase. Participants were also asked to report pain, fatigue or cognitive impairment (for example, memory loss). 

19 individuals were included in the analysis.

2 capsules A day of Mico-Rei, Ganoderma lucidum (Reishi HDT concentrated extract), before breakfast, and 3 capsules to the day of Mico-Lole, Hericium Erinaceus (HDT Leon Mamena Excerpt) Distributed between the morning, noon and the night (1-1-1), for 3 months (12 weeks). 

To measure the effects of the taking of Reishi and León's mane on the symptoms that persist after the conventional treatment of diseases transmitted by ticks, the participants were asked to they will complete the following questionnaires at different times of the study before the shot:

• Mycotherapy at 6 weeks and
• 12 weeks after starting mycotherapy.

The following three questionnaires were answered in different phases:

• Questionnaire of evaluation of Fatigue
• Pain questionnaire: McGill's brief questionnaire. [French version: Questionnaire de Douleur Saint-Antoine Abéré (QDSA).

Promising results

The answered questionnaires showed that participants with PTLDs reported and obtained an average 65% positive responses to the standardized questionnaires selected to control fatigue over 12 weeks. In addition, patients with PTLDS They also responded positively in 57% When asked questions related to pain intensity and improved their characteristics during the same period of 12 weeks of supplements administration.

In approximately half of the answers obtained in standardized questionnaires, it was observed that supplementation produced positive effects already on the 6th week of administration, which suggests a quite rapid improvement given the seriousness of the symptoms associated with SDPT.

Although more data is currently being analyzed, these results have demonstrated possible benefits induced by supplementation with two specific HDT fungi extracts in chronic Lyme.

Non -pharmaceutical interventions in patients with SDPT are rare, and most published studies on the treatment of this disease involve the use of antibiotics and other pharmaceutical interventions. However, the present study showed that the Use of specific fungal extracts can be effective in relieving symptoms in a short period.