Ergotinein: The biomolecule that everyone speaks to
The L-ertotryonein It is already beginning to be considered as the longevity and youth vitamin given the antioxidant action demonstrated to counteract the Oxidative stress (1).
Although it is mainly synthesized in mushrooms, fungi and soil bacteria, ergotinein is found in almost all human cells, which also suggests its importance for the promotion of human health.
Studies have shown that ergotinein can Preserve the length of telomeres and slow down their shortening in oxidative stress conditions, indicating the potential benefits of ergotinein for a healthy aging (2).
What does ergotinein do?
This incredible compound is very present in all our fabrics although even their levels decrease with age, especially from 60 years.
One of the most interesting ways to incorporate them into the body is through food. In this sense, pure fungi are one of the richest natural sources in ergotheonein. In the following lines we evaluate the great functional potential of this compound and how it can be found.
Studies with ergotinein
In the last decade, ergotinein, a natural amino acid modified with sulfur, has aroused great interest as a possible therapeutic compound. According to the published scientific evidence, the Ergotinein It has a great antioxidant and anti -inflammatory capacity.
In addition, new investigations suggest possible advantages for cognitive function, support for Immune system, the Prostate health and the cardiovascular well -being.
These virtues lead the scientific community to study their action on cardiovascular diseases, chronic inflammatory diseases, neuronal damage, cell aging and even cancer.
Effects of this natural biomolecule
L-Ergotinein, an amino acid composed of Histidine And a sulfur atom, was first identified by the French pharmacist Charles Tanret in the Cornez of the Centeno (Claviceps Purpurea) in 1909.
Mainly recognized by their antioxidant and cytoprotective properties Against oxidative stress, ergotinein also presents anti -inflammatory effects and detoxifies.
Since only certain microorganisms have the ability to synthesize ergotinein, this is acquired through food sources. Once ingested, ergotinein is absorbed in the gastrointestinal tract and is distributed to various organs, so it presents a good bioavailability.
The Ergotinein It is prone to accumulate in almost all cells and tissues, with higher concentrations in those subject to oxidative stress and injuries. Thus highlights its presence in erythrocytes, spleen, liver and eye tissues.
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Where is ergotinein
As observed, ergotinein is mainly obtained from mushrooms and fungi, but It can also be found in other foods such as seafood and meat in less.
Studies show that fruitful bodies (what we colloquially know how mushrooms) of basidiomycetes such as the Chaga, he Boletus edulis, the Oyster mushroom, the León hair, he Shiitake, and even the Cordyceps, stand out for their ergotinein levels.
However, given that some of these fungi cannot be consumed as food, it is recommended to take supplements with ergotinein to incorporate this valuable nutrient into the diet in relevant amounts.
Likewise, ergotinein is not the only compound of interest found in mushrooms the extracts of the aforementioned species have shown to have relevant amounts of ergosterol, ascorbic acid, flavonoids, tocopheroles, carotenoids, beta-glucanos and even phenolic compounds.
Ergotinein supplements, which one to choose?
Fungi are small organisms but with immense possibilities in its use as a nutritional complement. In fact, as we have just seen they contain powerful active biomolecules of interest.
Health professionals are the ones who can best guide us about our nutritional and functional needs, so we always recommend consulting expert professionals in this area.
On the other hand, the market offers infinite possibilities in the field of supplementation, so many that sometimes we can feel lost when choosing a quality supplement.
In this post we give some very specific recommendations to choose a quality supplement, but in summary, these are the guidelines that can help us choose the best supplement with ergotinein:
- Choose a trust laboratory, not a ghost company that we do not know processes, production standards, etc.
- Check the labeling that must inform about the amount of concrete active biomolecules contained in the supplement.
- Choose brands that are committed to the transparency policy and quality standards of the pharmaceutical sector such as the GMP seal, official ecological production stams (European seal), among others.
In Hifas da Terra we have been investigating fungi and their bioactive compounds for the development of nutritional supplements for more than 20 years. We collaborate with hospitals, health professionals and innovation centers to test our products and raise the quality of them by integrating the intelligent industry 4.0 into the productive and extractive processes of compounds of interest such as ergotinein.
Also, through our R&D projects (for example, Neurofood), we have developed innovative production systems that have allowed us to obtain fungi with greater amounts of Gaba and Ergotein, which moves in the final extracts that we sell in food supplements such as Mico-Chaga either Hifas-dotox.
Ergotinein: an intelligent antioxidant?
It has been shown that ergotinein acts as a protective agent of cells, fighting oxidative stress and inflammation.
In addition to these convincing properties, the mechanisms by which ergotinein penetrates our cells are equally surprising.
Its cellular collection seems to be governed by the expression of a specialized transporter, induced by oxidative stress, suggesting that Ergotinein intervenes precisely when cells need their help.
In addition, despite the initial assumptions, a 2017 study He revealed that supplementation with ergotinein in ihealthy and young He associated with a modest decrease in oxidative stress markers levelseither.
Ergotinein: a youth source
Promoting healthy aging is essential to improve the quality of life. The increase in oxidative stress as we age is a key factor related to age associated with age, particularly neurodegenerative disorders.
The consumption of a rich diet in antioxidant foods He has proven to have a substantial impact on the aging process. Strategically attacking aging mechanisms could be a valuable strategy to improve health in general.
The concentration of ergotinein in the bloodstream decreases with age and is related to the appearance of various diseases (3). Ergotinein (EGT), a hydrosoluble molecule provided by a specific transporter called OCTN1, presents promising indications in the investigation for its potential anti -aging attributes.
Egotheonein and cardiovascular system
In the cardiovascular field, ergotinein seems promising. Among the studies available, we observe that erythotinein supplementation is associated with beneficial effects In vitro and in animal models that have manifestations of heart disease such as type 2 diabetes, cardiovascular diseases, metabolic syndrome and NAFLD.
If we look at human beings, retrospective studies have identified associations between ergotinein consumption, blood levels and the improvement of oxidative stress markers and inflammation, as well as a lower risk of heart disease and mortality.
Ergotinein and brain
Due to the presence of a specific transporter that allows its arrival to the brain, some studies have analyzed their physiological role in brain function.
Thus, a publication indicates that the low levels of ergotinein in the blood of older people were associated with mild cognitive deterioration, as well as in patients suffering from several diseases, including Parkinson's disease. The low levels of erythotinein in plasma are also associated with neurodegeneration and cerebrovascular disease in dementia.
Finally, another study was able to demonstrate that ergotinein improves the function of memory in humans.
Summary: The compound with a promising future in cell aging
As Biotech specialized in the development of supplements from fungi, we work continuously to develop the best extraction processes For each of our fungi. Thus we guarantee the best concentrations of active ingredients in our products.
Ergotinein, a compound present naturally in fungi, has numerous benefits for human health. Clinical studies remain to accurately determine its nature, but there is no doubt that we will hear about it in the future, especially in its functional use at neurocognitive and antioxidant level.